Streptococcus sanguinis isolate displaying a phenotype with cross-resistance to several rRNA-targeting agents.

نویسندگان

  • Rodrigo E Mendes
  • Lalitagauri M Deshpande
  • Jihye Kim
  • Debra S Myers
  • James E Ross
  • Ronald N Jones
چکیده

This study describes a clinical case of a 71-year-old male with a history of ischemic cardiomyopathy after left ventricular assist device (LVAD) endocarditis caused by methicillin-resistant Staphylococcus epidermidis (MRSE) and a rare linezolid-resistant Streptococcus sanguinis strain (MIC, 32 μg/ml). The patient received courses of several antimicrobial agents, including linezolid for 79 days. The S. sanguinis strain had mutations in the 23S rRNA (T2211C, T2406C, G2576T, C2610T) and an amino acid substitution (N56D) in L22 and exhibited cross-resistance to ribosome-targeting agents.

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عنوان ژورنال:
  • Journal of clinical microbiology

دوره 51 8  شماره 

صفحات  -

تاریخ انتشار 2013